Amistad is the powerfully re-imagined history of one of the country's first battles for civil rights. In 1839 fifty-three enslaved Africans, led by a Mende rice farmer named Singbe-Pieh, staged a bloody rebellion on board the Amistad, a Spanish slaver from Cuba. The Amistad was intercepted by U.S. navy officers and towed to port in New London, Connecticut where the Africans were held for trial in New Haven.

Led by President Van Buren, the pro-slavery American government maintained that the Africans were Spanish property and should by returned to Havana to be tried for murder, but members of the fledgling abolitionist movement forced a series of trials to win their freedom, culminating at the Supreme Court, where the Amistads were defended by former President John Quincy Adams.