"The book is a state-of-the-art reference for understanding the role DNA methylation plays in human disease, particularly cancer. Written by leaders in the field, this compilation of articles outlines the best techniques to address questions concerning the cytosine methylation status of genomic DNA. It includes concepts, experimental models, and clinical uses of demethylating agents. The book also provides a balance between articles clarifying methodological details and general review chapters that offer broad biological perspectives on DNA methylation." "Covering fundamental theory, technologies, and applications, DNA Methylation: Approaches, Methods, and Applications presents the most current research on using DNA methylation to decipher the pathways involved in human disease. This is an invaluable handbook for researchers and clinicians interested in genetics and molecular biology, particularly epigenetic therapies and gene silencing."--BOOK JACKET.