Relying on the New Economics of Organizations (NEO), or New Institutionalism, Politics, Process, and American Trade Policy shows why conventional models do not adequately describe the formation of American trade policy. Rejecting both the pressure group model and the presidential-ascendancy model, this study's institution-based approach emphasizes the influence Congress has in setting trade policy, connecting theories of institutional design with the procedural details of regulating trade policy.

To reach her conclusions, Sharyn O'Halloran uses time series data and econometric analysis to test a set of propositions concerning trade policy. She examines detailed case studies and provides a comprehensive history of the institutions that govern trade policy making. Unlike most scholars who see trade policy as disparate and ad hoc, O'Halloran is able to explain both early and contemporary American trade policy in a consistent and integrated fashion.

She argues that a single set of procedures may lead to apparently different outcomes under differing initial conditions; therefore, the key is to identify the common logic, derived from constitutional imperatives, that underlies all policy outcomes.