The Zuni Man-Woman focuses on the life of We'wha (1849-96), the Zuni who was perhaps the most famous berdache (an individual who combined the work and traits of both men and women) in American Indian history. Through We'wha's exceptional life, Will Roscoe creates a vivid picture of an alternative gender role whose history has been hidden and almost forgotten.

Note: the language of "berdache" has been replaced by the term "Two-Spirit" by Two-Spirit American Indians.