The player controls Frankenstein's monster as he stomps through the streets of Ingolstadt, Bavaria, in the year 1793 seeking revenge against a certain man named Victor for rejecting him once he was created.[3] Since he is a product of artificial manufacturing, he is condemned and declared a monster by peasants and soldiers. The common folks that strive to kill Frankenstein's monster are highly ignorant about modern science and believe that he is truly a demon.

The game follows the plot of the movie closely with some alterations or padding, most notably the removal of Elizabeth's death scene yet her resurrection as an abomination is kept and she is fought as a boss that dies after being accidentally set on fire.