Special agent Leon S. Kennedy is sent on a mission to rescue the kidnapped U.S. President’s daughter Ashley. Finding his way to a rural village in Europe, he faces new threats that are a departure from the traditional lumbering zombie enemies of the earlier instalments in the series.

Leon battles horrific new creatures infested by a new threat called Las Plagas and faces off against an aggressive group of enemies including mind-controlled villagers that are tied to Los Illuminados - the mysterious cult behind the abduction.